心理健康和脏:认知衰退,抑郁症和住院老年人功能障碍之间的相互作用
Diana Moldovan1,2, Ina Kacso1,2, Lucreția Avram3,4
1Department of Nephrology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.
Journal of clinical medicine
|June 26, 2025
概括
老年患者经常经历认知衰退和抑郁症,这与恶化功能有关. 认知障碍与白尿增加和eGFR降低有关,突出显示了衰老中的脑连接.
科学领域:
- 老年病的医生 老年病的医生
- 腎臟病學 (nephrology) 是一種醫學專業.
- 精神病学是一个精神病学.
背景情况:
- 老龄化人口面临越来越多的精神健康障碍和慢性病 (CKD).
- 现有的关于老年人认知障碍,抑郁症和CKD之间的关系的数据是不确定的.
- 这项研究调查了老年人中这些疾病之间的复杂关联.
研究的目的:
- 检查老年住院患者认知障碍和抑郁症的患病率.
- 确定功能标志物 (eGFR,白蛋白尿) 和神经精神疾病之间的关系.
- 阐明衰老中脏健康和心理健康之间的相互作用.
主要方法:
- 对65岁及以上的719名住院患者的横截面分析.
- 使用老年抑郁量表 (GDS) 评估抑郁症,使用蒙特利尔认知评估 (MoCA) 评估认知功能.
- 通过估计的膜过率 (eGFR) 和专尿,通过逻辑回归来进行关联分析来评估功能.
主要成果:
- 观察到CKD (59.4%),认知障碍 (74%) 和抑郁症 (61.9%) 的高患病率.
- 慢性病患者的认知分数较差 (MoCA较低),抑郁症分数较高 (GDS较高).
- 增加的白蛋白尿与认知能力差异相关,而降低EGFR与认知能力下降和抑郁症症状增加有关.
结论:
- 认知障碍和抑郁症在住院的老年人中非常普遍.
- 认知能力下降与损伤标志物 (白蛋白尿,降低EGFR) 有关.
- 抑郁症状随着功能下降而恶化,这凸显了双向关系.
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