视垂体腺瘤患者的光学一致性断层扫描的价值及其与临床特征的关联:试点研究
Monika Duseikaite1, Alvita Vilkeviciute1, Igne Dumbliauskaite2
1Laboratory of Ophthalmology, Institute of Neuroscience, Lithuanian University of Health Sciences, Eivenių Str. 2, LT-50161 Kaunas, Lithuania.
Journal of clinical medicine
|June 26, 2025
概括
垂体腺瘤 (PA) 压缩光学,损害视力. 光学连贯断层扫描 (OCT) 显示PA患者视网膜神经纤维层 (RNFL) 厚度降低,与视野缺陷相关,有助于预测视觉恢复.
科学领域:
- 眼科医生 眼科 眼科
- 神经瘤学神经瘤学
- 医疗成像医学成像
背景情况:
- 下垂体腺瘤 (PA) 常常会因为缩压缩而导致视神经损伤.
- 评估视觉功能恢复涉及光学连贯断层扫描 (OCT) 视网膜神经纤维层 (RNFL) 和状细胞层 (GCL) 厚度,视野 (VF) 测试和磁共振成像 (MRI).
研究的目的:
- 研究视敏度 (VA),视野 (VF),RNFL,GCL变化和脑垂体腺瘤 (PA) 患者的MRI发现之间的关联.
主要方法:
- 一项涉及25名PA患者和27名健康对照者的比较研究.
- 光学连贯断层扫描 (OCT) 用于测量RNFL和GCL厚度,以及视神经盘直径.
- 对PA患者进行磁共振成像 (MRI).
主要成果:
- 与对照组相比,PA患者在象限中显著减少了RNFL厚度.
- 在特定的象限和组 (宏观PA,非活性PA,PA与细胞上延伸) 中观察到RNFL厚度的减少.
- 在PA中,高细胞延伸时,团细胞层 (GCL++) 厚度显著降低.
- 在RNFL厚度和视野缺陷之间发现了强烈的负相关性.
结论:
- 超标CT提供了有关PA患者视觉路径结构和功能变化的详细见解.
- 通过OCT测量RNFL厚度对于评估视觉功能和预测缺陷具有临床意义.
- 光盘边缘面积可能是一个比光盘面积更可靠的指标RNFL厚度变化在PA患者.
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