在老年黑人和白人美国人中,住宅隔离和表观遗传年龄加速
Reed DeAngelis1, Victoria Fisher2, John Dou3
1Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA.
概括
住宅隔离部分解释了黑人和白人美国人之间的生物衰老差异. 黑人个体表现出加速表观遗传衰老,压力和低教育等因素发挥作用,但不能完全解释差异.
科学领域:
- 社会学 社会学 社会学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 在黑人和白人美国人之间,预期寿命的种族差异仍然存在.
- 用表观遗传钟测量生物衰老,为健康差异提供了一个分子视角.
- 住宅隔离是健康影响衰老的潜在社会决定因素.
研究的目的:
- 调查住宅隔离在多大程度上解释了黑人和白人美国人之间的生物衰老差异.
- 评估与隔离和其他社会经济因素相关的表观遗传衰老加速.
主要方法:
- 分析了美国人改变生活研究 (第6波,2019) 中288名黑人和白人老年人的数据.
- 用五个表观遗传时钟 (GrimAge,PhenoAge,SkinBloodAge,HannumAge,HorvathAge) 来测量表观遗传年龄加速.
- 使用Getis-Ord G*统计和多层次建模来实现住宅隔离.
主要成果:
- 白人的表观遗传年龄特征在不同居住地点的白人中是相似的.
- 黑人个体与白人个体相比,呈现出大约三年的加速表观遗传年龄 (GrimAge),无论位置如何.
- 诸如低教育程度,房屋所有权,高创伤性压力和吸烟等因素解释了黑人隔离地区的表观遗传衰老加速,但在这些地区之外没有.
结论:
- 住宅隔离部分解释了黑人和白人美国人之间观察到的生物衰老差异.
- 虽然社会经济和与压力相关的因素有助于在隔离地区加速衰老,但它们无法解释生活在这些地区以外的黑人个体中观察到的表观遗传衰老加速.
- 需要进一步的研究来了解推动生物衰老种族差异的因素的复杂相互作用.
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