在子宫内暴露于PFAS的表观遗传后果:对发育和长期健康的影响
Abubakar Abdulkadir1, Shila Kandel1, Niya Lewis1
1Department of Biological Sciences and Chemistry, Southern University and A&M College, Baton Rouge, LA 70813, USA.
概括
产前暴露在per-和多基物质 (PFAS) 中可以改变胎儿的表观遗传学,影响长期健康. 这些环境污染物可能会通过表观遗传修饰增加患糖尿病和肥胖等疾病的风险.
科学领域:
- 环境表观遗传学环境表观遗传学
- 发展性毒理学 发展性毒理学
- 公共卫生 公共卫生
背景情况:
- 在子宫内暴露于和多基基物质 (PFAS) 是越来越严重的公共卫生问题.
- 暴露于PFAS可能会导致持久的表观遗传修饰,并产生持久的健康后果.
- 表观遗传变化是环境对发育影响的关键调解者.
研究的目的:
- 审查产前PFAS暴露对表观遗传机制的影响.
- 检查PFAS诱导的表观遗传变化与发育/长期健康结果之间的联系.
- 识别环境表观遗传学的知识差距和未来研究方向.
主要方法:
- 关于产前PFAS暴露和表观遗传学研究的文献综合.
- 对表观遗传修饰的分析,包括DNA甲基化,基因素修饰和非编码RNA调节.
- 专注于化合物特异性影响 (例如,PFOS,PFOA) 和胎盘组织变化.
主要成果:
- 产前暴露于PFAS会改变关键发育基因 (例如IGF2,MEST) 的DNA甲基化.
- 暴露于PFAS与生长,神经发育,免疫和代谢调节的中断有关.
- 特定的PFAS化合物表现出独特的表观遗传影响,影响荷尔蒙平衡和氧化应激.
结论:
- 产前暴露于PFAS会通过表观遗传破坏对胎儿发育和长期健康造成重大风险.
- 需要进一步的研究来了解表观遗传变化的持久性和性别特异性的影响.
- 干预和监管策略对于减轻这些环境污染物的风险至关重要.
关键词:
在PFAS中,有很多方法.发展效应的影响.内分泌干扰 干扰内分泌系统表观遗传学是指表观遗传学.基质子的修改 基质子的修改在子宫内,在子宫内.甲基化处理 甲基化处理这种ncRNAsRNAs.胎盘 胎盘 胎盘 胎盘更多相关视频
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