在自闭症学童和青少年中探索肠-大脑相互作用障碍
Carlos Alberto Velasco-Benítez1, Christian Andrés Rojas-Cerón1, Claudia Jimena Ortiz-Rivera2
1Departamento de Pediatría, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali 76001, Colombia.
Life (Basel, Switzerland)
|June 26, 2025
概括
在拉丁美洲,超过一半患有自闭症谱系障碍 (ASD) 的儿童患有肠-大脑相互作用障碍 (DGBIs). 功能性便秘是最常见的DGBI,中美洲的流行率更高.
科学领域:
- 胃肠病学 胃肠病学
- 神经发育障碍 神经发育障碍
- 儿科 儿科 儿科
背景情况:
- 根据罗马四号标准,肠-大脑相互作用障碍 (DGBIs) 影响全球23%的儿童.
- 拉丁美洲 (LA) 患有自闭症谱系障碍 (ASD) 的儿童中DGBI的患病率仍未研究.
- 这项研究解决了这个特定的儿科群体中关于DGBI的知识差距.
研究的目的:
- 确定LA地区ASD的学龄儿童和青少年中DGBI的流行率.
- 确定DGBIs与该组社会人口统计学/临床因素之间的潜在关联.
- 调查在LA内DGBI流行率的区域差异.
主要方法:
- 在多个洛杉矶城市中采用了观察和分析研究设计.
- 患有自闭症儿童的照顾者填写了儿童胃肠道症状的罗马四号问卷.
- 收集了社会人口统计,临床和家庭数据;统计分析包括OR和95%CI.
主要成果:
- 这项研究包括353名患有自闭症的儿童,其中大多数是男性 (78.8%) 和白人 (56.1%).
- 显著的58.9%的参与者出现了DGBIs,最常见的是功能性便秘 (27.2%).
- 来自中美洲的儿童患DGBI的可能性更高 (OR = 1.98,p = 0.0018).
结论:
- 超过一半的LA儿童和青少年患有ASD经历了DGBI.
- 功能性便秘是该队列中主要的DGBI.
- 来自中美洲的儿童患DGBI的风险增加.
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