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过敏炎症和动脉样硬化的结合:途径和临床影响 - - 综述
Mihaela Valcovici1, Mihai Sorin Iacob1,2, Abhinav Sharma1,2
1Department VI-Cardiology, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Life (Basel, Switzerland)
|June 26, 2025
概括
过敏性炎症,涉及乙氨基和巨细胞,有助于动脉样硬化和心血管疾病. 准过敏路径可能为心血管疾病提供新的治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 心血管疾病,特别是动脉样硬化,越来越多地与过敏性炎症有关.
- 过敏炎症的效应细胞可能会影响冠状动脉斑块的发展和不稳定性.
- 本综述探讨了过敏病理,动脉样硬化机制和临床关联之间的相互作用.
研究的目的:
- 检查连接过敏炎症和动脉样硬化的免疫机制.
- 审查过敏疾病和心血管疾病 (CVD) 之间的临床关联.
- 讨论管理这些相互关联的疾病的未来治疗前景.
主要方法:
- 在主要科学数据库中进行文献搜索 (2014-2024年).
- 包含的关键词:过敏性炎症,埃索诺菲尔,巨细胞,反应性氧物种,动脉样硬化,Th2细胞,细胞因子.
- 专注于流行病学研究和综述文章.
主要成果:
- 过敏性炎症通过乙氨基基基激活,反应性氧物种,巨细胞脱粒和内皮功能障碍导致动脉样硬化.
- Th2免疫反应 (IL-4,IL-5,IL-13) 和巨细胞活动是血管炎症和斑块进展的关键.
- 流行病学数据显示,患有喘和亚托皮性皮肤炎等慢性过敏疾病的患者心血管疾病增加.
结论:
- 动脉样硬化和过敏性炎症之间的相互作用表明心血管风险的潜在机制.
- 针对细胞因子抑制剂,巨细胞稳定剂和特定途径的新型治疗方法显示出希望.
- 需要进一步的研究来验证针对心血管治疗的向过敏途径,反之亦然.
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