合成,表征,生物评估,DFT计算和分子对接研究从Schiff基联体衍生的过渡金属复合体
Ibrahim Waziri1, Olaide O Wahab1, Grema A Mala2
1Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
Chemistry & biodiversity
|June 26, 2025
概括
新的希夫基础金属复合物对抗抗生素耐药性和氧化应激. (II) 复合物表现出强大的抗菌和抗氧化活性,提供了一种对抗耐药细菌有前途的战略.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 抗生素耐药性和氧化应激正在加剧全球卫生挑战.
- 为了应对这些威胁,急需创新的抗微生物战略.
- 希夫基联体及其金属复合物被用于生物学应用.
研究的目的:
- 为了合成和描述新型的希夫基联体 (HL) 和其金属复合物 (Co(II),Ni(II),Cu(II,Zn(II)).
- 评估合成化合物的抗菌和抗氧化活性.
- 调查复合体的结构,稳定性和机械方面的问题.
主要方法:
- 通过2 - 氨基和4 - 基甲的凝结合成希夫基联体 (HL).
- 使用光谱 (NMR,FTIR,UV-Vis,MS),热 (TGA) 和晶体技术进行表征.
- 抗菌活性 (MIC) 和抗氧化活性 (DPPH测定) 的评估,得到了 DFT 和分子对接研究的支持.
主要成果:
- 成功合成和表征了希夫基联体 (HL) 和其同质单核金属复合体 (ML2).
- 复合物在溶液中表现出良好的稳定性.
- 与自由联体相比,金属复合物表现出增强的抗菌和抗氧化活性,Ni (II) 复合物显示出更高的疗效.
- DFT和分子对接研究提供了对结构和结合性质的见解.
结论:
- 合成的希夫基础金属复合物,特别是Ni (II) 复合物,显示出作为抗微生物和抗氧化剂的显著潜力.
- 这些发现为开发针对抗生素耐药细菌和与氧化压力相关的疾病的新疗法提供了有希望的途径.
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