将氧异循环嵌入BODIPY中,以增强光动力学治疗的系统间交叉
Yu Zhang1, Zhiqiang Cui2, Jakub Širůček3,4
1Institute for Strategic Materials and Components, Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang, 110142, China. xdjiang@syuct.edu.cn.
Journal of materials chemistry. B
|June 26, 2025
概括
基于BODIPY的新近红外 (NIR) 染料被创造出来. 这些染料产生单片氧,通过线粒体损伤和光照射在体内有效地破坏瘤细胞.
科学领域:
- 有机化学 有机化学
- 摄影化学的使用.
- 生物医学工程 生物医学工程
背景情况:
- 二甲基 (BODIPY) 染料广泛用于各种应用.
- 开发具有增强光物理性质的新型NIR吸收染料对于先进的应用至关重要.
- 单点氧气生成是光动力学治疗的关键机制.
研究的目的:
- 合成新型的BODIPY衍生物,其中包含氧异循环.
- 研究这些新染料的光物理性质和单片氧生成能力.
- 评估自组装BODIPY纳米颗粒在体内瘤治疗中的有效性.
主要方法:
- 氧异环功能化的BODIPY染料的合成.
- 对于固态结构的确定,进行X射线晶体分析.
- 在溶液 (DMSO) 中进行光谱测量 (吸收,排放).
- 关于线粒体膜潜力和亡诱导的体外研究.
- 在动物瘤组织上的体内实验使用808nm激光照射.
主要成果:
- 成功制备了在NIR区域 (高达772 nm/807 nm) 吸收/发射的新型BODIPY染料.
- 通过X射线结晶学证实了固态结构.
- 证明了增强的系统间交叉,使无重原子单片氧产生.
- 自组装的BODIPY纳米粒子诱导了线粒体损伤,并在体内促进了瘤细胞的亡.
- 在808nm激光照射后观察到动物瘤组织的显著抑制.
结论:
- 氧异环组合有效调整BODIPY染料的NIR吸收和单一氧气生成.
- 自组装的BODIPY纳米颗粒显示出作为体内瘤治疗的光动力治疗剂的前景.
- 开发的无重原子系统为光动力学治疗应用提供了潜在的替代方案.
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