平均体积 (MCV) 是一种与COVID-19死亡风险相关的血液学生物标志物
Víctor Bernal-Dolores1, José Manuel Reyes-Ruiz1, Kim Rodríguez-Relingh1
1Unidad Médica de Alta Especialidad, Hospital de Especialidades No. 14, Centro Médico Nacional "Adolfo Ruiz Cortines", Instituto Mexicano del Seguro Social (IMSS), Veracruz, Mexico.
Biomarkers in medicine
|June 26, 2025
概括
升高的平均体积 (MCV) 和血小板与淋巴细胞比率 (PLR) 预测了COVID-19死亡率. 患有MCV> 89 fL或PLR> 418.08的患者面临更高的因SARS-CoV-2感染的住院死亡风险.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 预测COVID-19死亡率对于患者管理至关重要.
- 确定可靠的生物标志物来进行风险分层是至关重要的.
研究的目的:
- 为了研究COVID-19死亡率的平均体积 (MCV) 的预测值.
- 评估其他血液学参数,如NLR,PLR和SII作为死亡率预测指标.
主要方法:
- 这是一项对122名COVID-19患者的回顾性,单中心,纵向研究.
- 对MCV,中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR) 和全身免疫炎症指数 (SII) 的分析.
- 使用尤登指数确定最佳截止值,并通过AUC评估预测准确度.
主要成果:
- 与幸存者相比,非幸存者表现出明显更高的MCV,NLR,PLR和SII水平 (p <0.05).
- 死亡率预测的最佳切线值为MCV>89 fL,NLR>8.69,PLR>418.08和SII>2149.36.
- MCV> 89 fL和PLR> 418.08独立地与增加的COVID-19死亡风险相关 (OR分别为3.65和5.08).
结论:
- 住院时的MCV> 89 fL和PLR> 418.08是增加COVID-19死亡率的重要预测因素.
- 这些血液学参数为COVID-19患者的风险分层提供了宝贵的见解.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
353
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
353
02:45Blood Transfusion and Agglutination
11.3K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
11.3K
01:47Lung Capacity
51.5K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
51.5K