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Updated: Sep 18, 2025

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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通过基于生理学的动力模型估计内源性形成的N-尼托胺的生物可用度

Max Spaenig1, Matthias Vogel2, Tanja Hansen1

  • 1Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.

ALTEX
|June 26, 2025
PubMed
概括

从像埃纳拉普利尔这样的药物中内源性形成的氨酸 (NA) 可以超过安全摄入限值. 基于生理学的动力学 (PBK) 建模表明存在重大风险,强调需要先进的制药杂质评估.

关键词:
ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME这是NDSRI的NDSRI.药物动力学 (PK) 是指

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