Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neural Regulation01:37

Neural Regulation

40.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Brain network pathophysiology in dystonia.

Dystonia (Lausanne, Switzerland)·2026
Same author

Parkinson's disease: Individual placebo responses are predicted by baseline expression of a striato-limbic network.

Research square·2026
Same author

Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.

medRxiv : the preprint server for health sciences·2026
Same author

Preventing Parkinson's disease in the context of movement disorders: a narrative review of current evidence and future directions.

Neurological research and practice·2026
Same author

Non-invasive identification of brain signatures of acute liver injury.

Theranostics·2026
Same author

Utility of [<sup>18</sup>F]PI-2620 as Universal Biomarker for the Amyloid/Tau/Neurodegeneration Classification of Alzheimer Disease: An Exploratory Study with Dual-Phase PET Imaging.

AJNR. American journal of neuroradiology·2026

相关实验视频

Updated: Sep 18, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.8K

帕金森病相关模式 (PDRP) 使用休息状态功能性MRI确定:验证研究验证研究.

Andrea Rommal1, An Vo1, Katharina A Schindlbeck1

  • 1Center for Neurosciences, The Feinstein Institutes for Medical Research, Manhasset, NY, 11030, USA.

Neuroimage. Reports
|June 26, 2025
PubMed
概括

休息状态fMRI (rs-fMRI) 成功地在不同部位识别了可重现的帕金森病 (PD) 大脑模式 (fPDRP),为疾病评估提供了PET扫描的非侵入性替代方案.

关键词:
大脑网络 大脑网络独立的组件分析组件分析帕金森病的疾病.休息状态的功能性MRI.

更多相关视频

fMRI Validation of fNIRS Measurements During a Naturalistic Task
10:36

fMRI Validation of fNIRS Measurements During a Naturalistic Task

Published on: June 15, 2015

21.0K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K

相关实验视频

Last Updated: Sep 18, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.8K
fMRI Validation of fNIRS Measurements During a Naturalistic Task
10:36

fMRI Validation of fNIRS Measurements During a Naturalistic Task

Published on: June 15, 2015

21.0K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K

科学领域:

  • 神经成像是一种神经成像.
  • 医学物理 医学物理
  • 神经学 神经学

背景情况:

  • 代谢成像,像PET,检测疾病模式,但涉及辐射暴露.
  • 与帕金森病相关的模式 (PDRP) 是一个经过验证的代谢拓.
  • 寻求非侵入性方法来检测疾病网络.

研究的目的:

  • 为了验证不同患者群体和地点的非侵入性静止状态fMRI (rs-fMRI) 衍生的帕金森病模式 (fPDRP).
  • 为了比较两个独立的队列之间的fPDRP地形和表达的复制性.
  • 评估帕金森病患者fPDRP表达与临床运动残疾的相关性.

主要方法:

  • 在rs-fMRI数据上使用独立组件分析 (ICA) 和引导重新采样.
  • 在德国科隆的一个新队列中验证了fPDRPNS模式,并确定了一个本地模式,fPDRPCOL.
  • 将fPDRPNS和fPDRPCOL之间的地形相似性和表达水平进行比较,并与临床运动分数相关联.

主要成果:

  • fPDRPNS和fPDRPCOL显示出地形相似性,其中主要贡献来自面,白色球体,子,小脑和乳腺体.
  • 两个fPDRP模式的表达水平在每个患者群体内都有显著的相关性.
  • 与对照组相比,在PD患者中观察到fPDRPCOL核心表达异常升高,与运动残疾的相关性是显著的.

结论:

  • rs-fMRI衍生 fPDRP 网络可以在不同患者群体,临床场所和扫描平台中复制.
  • 这种非侵入性的rs-fMRI方法为在帕金森病中对疾病网络的定量评估提供了代谢性PET的可行替代方案.
  • 这些发现支持使用rs-fMRI用于临床疾病监测和研究.