青少年对威胁反应的神经模式预测了在COVID-19浪潮期间对内化症状的脆弱性和弹性
Anna Tyborowska1,2, Yvonne van den Berg1, Mahur M Hashemi1,2
1Behavioural Science Institute, Radboud University, Thomas van Aquinostraat 4, 6525 GD, Nijmegen, the Netherlands.
Neuroimage. Reports
|June 26, 2025
概括
神经威胁反应,特别是杏仁体活动,预测了对压力的弹性. 充分的威胁歧视信号的弹性,而过度反应的小威胁表明脆弱性,焦虑在充满挑战的时期,如COVID-19封锁.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 压力研究 压力研究
背景情况:
- 防御性压力反应 (结,战斗或逃跑) 对于应对威胁至关重要.
- 杏仁体活动是抗压能力的潜在标志物.
- 随着COVID-19的封锁,潜在的调查出现了普遍的压力因素.
研究的目的:
- 为了调查神经威胁响应在COVID-19封锁期间症状发展的预测价值.
- 检查杏仁体活动作为青少年应激弹性标志物.
- 了解威胁感知如何影响长期压力下焦虑的发展.
主要方法:
- 在17岁的青少年 (n=64) 中使用fMRI适应的Go/Nogo Under Threat (GUNT) 任务.
- 威胁反应的量化神经 (杏仁体,甲状腺,皮层下) 和生理标志物.
- 在COVID-19封锁期间进行了后续评估 (22-23岁),测量了焦虑症状.
主要成果:
- 17岁时的威胁预测性杏仁体反应预测了锁定期间的压力因素弹性 (较低的焦虑).
- 在17岁时对低威胁线索的更强的杏仁体反应与增加的焦虑症状有关.
- 这些发现独立于生命早期的压力和COVID-19压力负担.
结论:
- 对急性威胁的杏仁体反应作为对现实生活压力因素的弹性标记.
- 杏仁体对威胁进行充分的歧视,表明了弹性.
- 对低威胁的提升的杏仁体反应预测了对焦虑的脆弱性,强调了威胁感知在适应性应对中的重要性.
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