医院内抗生素使用与重症患者的长期结果之间的关联
Parker Burrows1, Ruth-Ann Brown1, Abigail Samuelsen2
1Department of Anesthesiology and Perioperative Medicine, Penn State Milton S Hershey Medical Center, Hershey, PA 17036, USA.
危急病患者的抗生素持续时间 (AD) 较长会增加住院时间,但不会降低死亡率或再入院率. 建议使用较短的抗生素疗程,以尽量减少并发症,并改善抗生素管理.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素持续时间 (AD) 和无抗生素日 (AFD) 是管理重症患者的关键指标.
- 优化AD对于患者的治疗结果和打击抗菌素耐药性至关重要.
研究的目的:
- 评估AD和AFD与重病成人住院和出院后的结果之间的关联.
- 为了确定延长AD是否影响死亡率,再录取率和二次感染率.
主要方法:
- 一项前性观察性研究对126名患重病的成年人进行了观察.
- 用多变量分析和Cox比例危险建模来评估结果.
- 规范化抗生素暴露与累积的二次感染发作进行了分析.
主要成果:
- 较长的AD与增加的住院时间相关 (约. 每年增加0.93天).
- 阿迪并没有预测一年死亡率或再录取.
- 增加抗生素暴露与更高的二次感染率有关.
结论:
- 在重症患者中,延长的AD延长了住院时间,但没有改善存活率或减少再入院.
- 研究结果强调需要有效的抗生素管理,有利于更短,更有针对性的疗程.
- 尽量减少AD可以帮助减少并发症和预防二次感染.
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