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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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摄入量与功能下降,发生慢性病和发生心血管疾病之间的关系
Javier A Neyra1,2, Ronit Katz3, Stephen Kritchevsky4
1Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.
Clinical kidney journal
|June 26, 2025
概括
饮食中较高的摄入量与老年人慢性病 (CKD) 和功能下降的风险降低有关. 然而,摄入量与心血管疾病 (CVD) 风险没有显著的关联.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 以前的研究表明,较高的 (Mg) 摄入量与中风,心力衰竭和死亡率的风险降低有关.
- 关于摄入量与病结局之间的关联的数据有限.
- 这项研究调查了饮食中的摄入量与心血管疾病 (CVD),慢性病 (CKD) 和老年人功能下降的发生率之间的关系.
研究的目的:
- 检查一种假设,即饮食中的摄入量增加与心血管疾病,CKD和功能下降的发病率较低有关.
- 评估饮食摄入的Mg与脏和心血管结果在社区居住的老年人队列的独立关联.
主要方法:
- 利用了来自健康,衰老和身体组成研究的数据,这是3075名老年人的观察队列.
- 通过经过验证的饮食调查来评估饮食摄入的Mg.
- 结局包括估计的膜过率 (eGFR) 或发生的CKD下降≥30%. 事件CVD被定义为冠心病,心力衰竭,中风或心血管死亡率.
- 用多变量波桑回归和考克斯比例危险模型来分析这些关联.
主要成果:
- 分析包括2682名参与者,平均每日食摄入量为278毫克/天.
- 较高的摄入量独立地与30%的eGFR下降风险较低有关 (每次SD的IRR:0.79;95%CI:0.66,0.93).
- 更高的摄入量也与较低的发生性CKD风险有关 (每次SD的IRR:0.84;95%CI:0.73,0.96).
- 没有发现摄入量与整体心脏病发作 (调整HR:0.98;95%CI:0.85,1.13) 之间有显著的关联.
结论:
- 饮食中较高的摄入量与老年人功能下降和发生慢性病的风险降低有关.
- 该研究发现,摄入量与发生心血管疾病的风险之间没有显著的关联.
- 需要进一步的研究来探索补充剂对脏结果的影响.
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