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Updated: Sep 18, 2025

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract ECME-based Three-dimensional System
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来自条件化巨细胞和乳腺癌细胞的细胞外囊泡之间的细胞间通信驱动了内分泌疗法耐药性的驱动

María C Rodriguez-Baili1, Miguel Palma-Cobo2, César G Prucca1

  • 1Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, CONICET, Universidad Nacional de Córdoba-CIQUIBIC, Córdoba, Argentina.

Frontiers in cell and developmental biology
|June 26, 2025
PubMed
概括

巨细胞衍生的细胞外囊泡 (EVs) 通过增加癌症干细胞特性和驱动免疫抑制,促进雌激素受体阳性乳腺癌的内分泌耐药性. 针对这些EV可能为乳腺癌患者提供新的治疗策略.

关键词:
乳腺癌 乳腺癌 乳腺癌癌症干细胞 (CSS) 是一种癌症干细胞.内分泌耐药性 内分泌耐药性表皮细胞-介质细胞过渡 (EMT)雌激素受体阳性 (ER+) 的细胞外囊泡 (EVs) 的产生.瘤微环境 (TME) 是指瘤的微环境.与瘤相关的巨细胞 (TAMs)

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