系统性炎症反应指数与慢性血栓栓塞性肺高血压疾病严重程度和不良结果的关联
Sicong Li1, Luyang Gao1, Sicheng Zhang1
1Center for Respiratory and Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China.
Journal of inflammation research
|June 26, 2025
概括
系统性炎症反应指数 (SIRI) 是慢性血栓栓塞性肺高血压 (CTEPH) 的一个有价值的预后标志物. 升高的SIRI水平与疾病严重程度相关,并独立预测CTEPH患者的临床恶化.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 炎症研究 炎症研究
背景情况:
- 综合性炎症标志物,如全身炎症反应指数 (SIRI),与心血管疾病的进展有关.
- 在慢性血栓栓塞性肺高血压 (CTEPH) 中SIRI的预后作用尚未得到充分证实.
- 这项研究调查了SIRI和CTEPH严重程度和结果之间的关联.
研究的目的:
- 为了澄清SIRI在被诊断为CTEPH的患者中的预测价值.
- 为了确定SIRI是否与已确定的CTEPH严重性标志物相关.
- 评估SIRI在CTEPH中对不良临床结果的独立预测能力.
主要方法:
- 对383名CTEPH患者进行了回顾性队列研究.
- 使用接收器操作特征 (ROC) 曲线分析来确定SIRI的诊断性能和最佳切断.
- 卡普兰-梅尔分析和考克斯比例危险模型评估了SIRI和临床恶化之间的关系.
主要成果:
- SIRI与6分钟的步行距离,N-终端脑前性尿素和血液动力学参数有显著的相关性.
- 患有SIRI≥0.80的患者的存活率明显降低,临床恶化时间缩短 (P<0.01).
- SIRI独立预测了临床恶化 (HR 2.033) 并改善了COMPERA 2.0风险评分的预测值.
结论:
- 系统性炎症反应指数 (SIRI) 作为CTEPH的显著预后标志物.
- SIRI与疾病严重程度相关,并独立预测临床恶化.
- 将SIRI与COMPERA 2.0风险评分相结合,可以提高CTEPH患者的预后准确性.
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