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听力损失与轻度认知障碍患者的默认模式网络连接性下降有关

Nicole Grant^1,2,3,4,5, Natalie Phillips^1,2,3,4,6,5

¹Department of Psychology, Concordia University, Montreal Quebec, Canada.

Neuroimage. Reports

|June 26, 2025

概括

轻度认知障碍 (MCI) 患者的听力损失 (HL) 与大脑连接性降低有关. 这可能解释了为什么听力损失会增加MCI患者的痴呆风险.

科学领域:

神经科学是一个神经科学.
老年学是一门学科.
听力学听力学是指听力学.

背景情况:

轻度认知障碍 (MCI) 和听力损失 (HL) 是痴呆的独立风险因素.
这两种情况都与功能性大脑连接的改变有关.
MCI,HL和大脑连接之间的相互作用仍未得到充分研究.

研究的目的:

调查MCI的老年人中纯色调听力损失和默认模式网络 (DMN) 连接之间的关系.
在这个人群中探索语音接收值和DMN连接之间的关联.

主要方法:

休息状态fMRI和独立组件分析被用于评估DMN连接性.
包括94名患有MCI的老年人,按正常听力 (n=60) 或听力损失 (n=34) 分类.
使用ANOVA和线性回归分析来比较群体并评估关系.

主要成果:

与MCI和纯色HL患者相比,与MCI和正常听力患者相比,MCI和纯色HL患者的DMN连接性降低了尾巴和丘脑.
在语音接收值和DMN连接之间没有发现显著的关联.

结论:

患有MCI的个体的听力损失与DMN内的功能连接性降低有关.
这种减少的连接性可能是MCI和HL同时发生的个体认知衰退和痴呆的风险增加的基础.

关键词:

默认模式的网络模式是默认模式.功能连接性的功能连接性.听力损失听力损失轻度认知障碍轻度认知障碍休息状态的休息状态.

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