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患有自闭症谱系障碍或强迫症儿童的认知控制的发展:一项纵向fMRI研究

Bram Gooskens¹, Dienke J Bos¹, Jilly Naaijen^2,3

¹Department of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Neuroimage. Reports

|June 26, 2025

概括

患有自闭症谱系障碍 (ASD) 和强迫症 (OCD) 的儿童的认知控制发展与典型的发育儿童相似,尽管在OCD中存在一些微妙的脑活动差异.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
儿童精神病学儿童精神病学

背景情况:

重复性行为是自闭症谱系障碍 (ASD) 和强迫症 (OCD) 的标志.
在这些条件下,认知控制发展和重复性行为之间的关系尚未完全理解.
了解神经电路对于开发有效干预措施至关重要.

研究的目的:

研究ASD和强迫症儿童认知控制的发展轨迹.
检查认知控制与重复行为之间的关联.
使用功能磁共振成像 (fMRI) 探索神经相关性.

主要方法:

一项多中心的纵向研究 (TACTICS) 追踪了患有ASD,强迫症和典型发育 (TD) 控制的儿童.
使用fMRI和修改后的停止信号任务来评估童年后期 (8-14岁) 的认知控制.
参与者包括95名基线儿童和53名随访儿童.

主要成果:

停止信号反应时间 (SSRT) 在所有组中随着年龄的增长而改善.
在ASD或强迫症组中,重复性行为与停止信号任务性能没有相关性.
两组之间没有发现整个大脑活动的显著差异,尽管强迫症随着时间的推移显示右前中心活动增加.

结论:

通过停止信号任务测量认知控制的发展,在ASD/OCD和TD儿童之间在很大程度上是可比的.
在强迫症组中观察到脑活动的微妙发育变化.
研究结果表明,认知控制的发展不是儿童时期这些障碍的主要差异化因素.

关键词:

自闭症谱系障碍自闭症谱系障碍认知控制认知控制强迫症是一种强迫症.重复的行为重复的行为.功能磁力共振成像 (fMRI) 是一种

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