在辅助生殖技术怀孕中对唐氏综合征的产前查:系统性审查
Fatemeh Zahra Meamar1, Mitra Savabi-Esfahani2, Tahmineh Farajkhoda3
1Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Reproductive Sciences and Sexual Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
International journal of reproductive biomedicine
|June 26, 2025
概括
在辅助生殖技术 (ART) 怀孕中解释唐氏综合征查是复杂的. 这次审查强调了ART怀孕中的不同标志物水平,建议对IVF和ICSI进行调整的查.
科学领域:
- 产科和妇科 产科和妇科
- 产前诊断 在产前诊断
- 生殖医学 生殖医学
背景情况:
- 在辅助生殖技术 (ART) 怀孕中解释唐氏综合征查结果存在重大挑战.
- 在ART怀孕中,假阳性结果会给准带来巨大的心理痛苦.
- 有限的研究重点是解释在ART后怀孕中唐氏综合征的血清和超声波标志物.
研究的目的:
- 调查血清查和成像用于在ART怀孕中产前诊断唐氏综合征.
- 提高对ART怀孕中产前查结果的理解和正确解释.
主要方法:
- 进行了对30篇文章的系统审查.
- 在主要数据库 (PubMed, Web of Science, Scopus, SID, Google Scholar) 中以英语和波斯语进行搜索,没有时间限制,直到2024年1月.
- 使用了PRISMA,STROBE和CONSORT的指导方针.
主要成果:
- 第一个三个月的查显示,在ART怀孕 (IVF/ICSI) 中,与怀孕相关的血蛋白-A较低,自由β-人类胆管性腺激素较高.
- 在一些ART怀孕中观察到部透光度增加.
- 第二个三个月的查表明,在一些ART怀孕中,抑制蛋白-A,α-fetoprotein和未结合的醇水平发生变化.
结论:
- 在ART怀孕中标志物水平的变化受到排卵诱导,多胎妊娠和ART技术 (IVF/ICSI) 等因素的影响.
- 孕产妇血清标记度,特别是自由β-人类胆管性淋巴激素和与怀孕相关的血蛋白-A,需要对IVF和ICSI单独进行调整的解释.
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