在美国成年人中,多环芳暴露与与代谢功能障碍相关的脂肪性肝病之间的关联
Jiajun Wu1, Shaoqian Cui1, Xuekui Li2
1Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, China.
Frontiers in public health
|June 26, 2025
概括
对多环芳 (PAH) 的暴露与美国成年人代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险增加有关. 这种关联对于单个PAH及其组合作用都是如此.
科学领域:
- 环境健康 环境健康
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的公共卫生问题.
- 多环芳 (PAH) 是具有潜在不利健康影响的环境污染物.
研究的目的:
- 调查PAHs对美国成年人MASLD的单独和综合影响.
- 评估尿路PAH代谢物与MASLD患病率之间的关联.
主要方法:
- 利用了来自2007-2016年NHANES的3130名美国成年人 (20岁以上) 的数据.
- 通过Poisson,贝叶斯核心机器回归 (BKMR) 和加权定量和 (WQS) 回归模型分析了六种尿液PAH代谢物.
主要成果:
- 特定PAHs (2-NAP,2-FLU,1-PHE,1-PYR) 的更高暴露四分位数与MASLD有显著的关联.
- 在混合PAH和MASLD之间,BKMR表明了积极的趋势.
- 六种PAH的WQS指数显示与MASLD有显著的关系 (OR:1.25 [1.06, 1.49]).
结论:
- 单独或组合暴露于PAH与MASLD的风险增加有关.
- 研究结果强调了环境污染物在肝病发展中的潜在作用.
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