老年人群中皮下和静脉注射塞弗特里亚克松的药理动力学:PhASAge研究
Claire Roubaud-Baudron1,2, Héloïse Fauchon3, Françoise Stanke-Labesque4
1CHU Bordeaux, Pôle de Gérontologie Clinique, Bordeaux, France.
Open forum infectious diseases
|June 26, 2025
概括
在老年患者中,皮下使用塞夫特里亚克森的药理动力学和药理动力学与静脉注射途径相似. 这种非标签的做法显示出类似的疗效和安全性,支持其在老年人群中的更广泛使用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
- 传染性疾病 传染性疾病
背景情况:
- 塞夫特里亚在法国通常是通过皮下注射的,特别是在老年患者中,尽管它是非标签用途.
- 这种做法需要对其在这个人群中的药理动力学和药理动力学特征有充分的了解.
研究的目的:
- 在老年患者中评估皮下与静脉注射塞夫triaxone的药理动力学 (PK),药理动力学 (PD) 和耐受性.
- 为了评估目标实现的概率 (PTA) 对于两个管理路径.
主要方法:
- 从47名老年患者 (≥65岁) 的稳定状态血度来开发一个人群PK模型,每24小时接受1g二.
- 对静脉注射和皮下注射途径进行了生物可用性,PTA和不良事件 (AE) 的分析.
主要成果:
- 皮下使用的塞夫特里亚克森具有99%的生物可用性,与PTA的生物可用性相当于静脉注射或超过静脉注射.
- 每24小时服用1g或2g的皮下剂量表现为可接受的PTA,以及正常或中度功能患者的低过度暴露风险.
- 局部AE更频繁 (13%) 的皮下给药 (过渡性胀) 与静脉注射 (1.5%),没有严重事件报告.
结论:
- 皮下使用的塞夫特里亚克森在药理动力学和药理动力学上与老年患者的静脉注射相似.
- 这些研究结果支持在老年人中使用皮下注射塞夫,使剂量要求与已建立的静脉注射方案保持一致.
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