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Updated: Sep 18, 2025

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
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斑马鱼ABCB4的结构揭示了多药物运输器的形态景观的功能影响

Jingyu Zhan, Chao-Ming Hsieh, Lothar Esser

    bioRxiv : the preprint server for biology
    |June 26, 2025
    PubMed
    概括

    斑马鱼Abcb4,人类P-gp的同类,通过动态运动显示一个液体结合口袋. 这种灵活性解释了ABC输送器如何识别和输出各种药物,这是多药耐药性的关键方面.

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