激发性驱动到球外段的刺激驱动促进非人类灵长类动物的行动启动
Atsushi Yoshida1,2, Okihide Hikosaka1
1Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
bioRxiv : the preprint server for biology
|June 26, 2025
概括
灵长类动物的白球体 (GPe) 的外部部分积极促进行动并抑制运动. 这个基底腺核在基于奖励的决策和运动控制中起着双重作用.
科学领域:
- 神经科学是一个神经科学.
- 灵长类神经生理学
- 基底性 Ganglia 研究 研究
背景情况:
- 传统上,外部球体 (GPe) 被视为通过基底腺间接通路单独调解运动抑制.
- 在动物中新出现的证据表明,GPe也可能积极促进行动,这表明它具有更复杂的功能表.
- 了解GPe在灵长类动物中的作用对于破译复杂的运动控制和决策过程至关重要.
研究的目的:
- 研究灵长类GPe内部的功能多样性,特别是研究其在行动启动和抑制中的作用.
- 确定灵长类GPe是否与动物对应物一样,有助于运动促进和抑制.
- 探索GPe参与基于奖励的决策任务.
主要方法:
- 在GPe中记录了两个的单个单元活动,它们执行了一项涉及接受/拒绝对象的顺序选择任务.
- 分析神经元发射模式,以识别不同的功能集群.
- 利用尾背GPe中谷氨酸受体的局部药理学阻断来评估因果作用.
主要成果:
- 在GPe中确定了三个神经元集群,与任务执行相关的不同发射模式.
- 集群显示在更快的接受次序 (促进) 之前和相关的活动增加,在拒绝次序 (抑制) 期间活动减少.
- 药物阻断影响了萨卡德启动和减少排斥频率,证实了GPe刺激驱动器在运动控制中的因果作用.
结论:
- 灵长类GPe表现出功能多样性,同时调解运动促进和主动抑制,挑战传统的抑制作用.
- 这些发现凸显了基底腺网络中电路和细胞类型特定分析的重要性.
- 这项研究对理解复杂决策条件下运动障碍的正常运动功能和病理生理学有影响.
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