肥胖如何使乳腺癌护理复杂化:从对病例报告的系统审查中得出的见解
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Updated: Sep 18, 2025
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Adam M Bowen1,2, Dania Baraka2, Bilal Ali2
1Hematology Oncology, Upstate University Hospital, Syracuse, USA.
Cureus
|June 26, 2025
概括
肥胖使乳腺癌的治疗复杂化,导致诊断延迟和治疗问题. 了解这些特定于肥胖的风险对于改善患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 代谢障碍 代谢障碍 代谢障碍
- 临床医学 临床医学
背景情况:
- 全球肥胖率的上升与乳腺癌发病率的增加相交.
- 过度肥胖在乳腺癌诊断,治疗和患者治疗结果方面带来了挑战.
- 在乳腺癌护理中,肥胖的个体级临床细微差别不足.
研究的目的:
- 系统地审查基于案例的证据,以了解肥胖如何影响乳腺癌的诊断和治疗.
- 在肥胖乳腺癌患者中确定特定的诊断延迟和治疗并发症.
- 为个性化乳腺癌护理策略突出肥胖特异性风险.
主要方法:
- 按照PRISMA 2020指南进行的系统审查.
- 在PubMed,Embase,Scopus和谷歌学者中搜索英语语言的案例报告/系列.
- 包括详细介绍患有乳腺癌的肥胖女性诊断/治疗并发症的研究;使用Joanna Briggs Institute检查清单评估质量.
主要成果:
- 从8份报告中,有9名患者符合纳入标准.
- 肥胖影响了通过延迟诊断,增加手术并发症 (感染,重建失败),改变药物代谢 (毒性/低剂量) 和多病症的治疗.
- 病例包括罕见的感染,内分泌治疗,腹膜外科手术后的吸收不良以及放大毒性.
结论:
- 肥胖在乳腺癌的诊断和治疗过程中存在重大临床障碍.
- 现实世界的案例揭示了在人口研究中并不总是明显的机制和程序挑战.
- 提高对肥胖特异性风险的认识可以优化乳腺癌治疗疗效和患者的治疗结果.
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