在口腔状细胞癌中长非编码RNA的表达及其对放射治疗反应的影响
Gurumoorthy An1, Ramesh M2, Ramajayam Govindan3
1Department of Surgical Oncology, Government Rajaji Hospital, Madurai, IND.
Cureus
|June 26, 2025
概括
手术前长非编码RNAOIP5和CCAT1的血水平与口腔状细胞癌患者的放射治疗耐药性有关. 这一发现表明它们作为预测治疗反应的生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 与放射治疗 (RT) 同步进行全身疗法是口腔瘤的标准治疗方法.
- 由于瘤微环境的异质性,患者对RT的反应有所不同,可能涉及长非编码RNA (lncRNAs).
- 识别生物标志物来预测RT反应对于口腔状细胞癌 (OSCC) 的个性化治疗策略至关重要.
研究的目的:
- 在OSCC组织和血中评估五种lncRNAs (OIP5,CCAT1,MALAT1,MEG3,UCA1) 的过度表达.
- 为了将lncRNA表达与患者对放射治疗的反应相关联.
- 评估使用血lncRNA表达作为RT反应评估的生物标志物的可行性.
主要方法:
- 这是一项前性研究,涉及41名OSCC患者接受了激进的RT.
- 在RT之前收集原发性瘤组织和血样本,以通过RT-PCR检测lncRNA.
- 使用FDG-PET/CT扫描和RECIST 1.1标准评估治疗反应;对响应者和不响应者之间的血lncRNA水平进行比较.
主要成果:
- 与完全响应者 (CR) 相比,在进展性疾病 (PD) 的患者中观察到 lncRNAs OIP5 (p=0.018) 和CCAT1 (p=0.016) 在治疗前显著更高的血表达.
- 其他研究的lncRNAs (MALAT1,MEG3,UCA1) 的差异性过度表达与该队列的RT反应没有显著相关.
- 该研究表明,测量血lncRNA水平的可行性是潜在的生物标志物应用.
结论:
- 手术前的血OIP5和CCAT1表达水平与口腔状细胞癌中对放射治疗的耐药性有关.
- 这些lncRNAs显示出在OSCC患者中作为放射治疗反应的预测生物标志物的潜力.
- 需要进一步的验证研究来确定血OIP5和CCAT1作为RT反应生物标志物的临床实用性.
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