多发性硬化症的并发症和心血管风险因素
Mahdi Barzegar1,2, Sara Samadzadeh3,4,5, Kosar Kohandel6
1Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
概括
患有多发性硬化症 (MS) 的患者经常出现并发症,包括心血管疾病 (CVD). 在这个人群中,代谢综合征和胰岛素抵抗是常见的,通常与残疾有关.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 多发性硬化症 (MS) 经常与心血管疾病 (CVD) 以及其危险因素有关.
- 调查患有多发性硬化症 (pwMS) 患者的并发性疾病患病率对于综合护理至关重要.
研究的目的:
- 确定多发性硬化症患者的并发症,特别是心血管疾病的患病率.
- 评估pwMS中并发症,残疾和心血管风险之间的关联.
主要方法:
- 两个MS队列 (德黑兰和伊斯法罕) 的回顾性和前性研究.
- 测量生物医学参数,包括代谢综合征 (MetS) 和胰岛素抵抗 (IR).
- 10年弗雷明汉风险评分 (FRS) 计算用于心血管风险评估.
主要成果:
- 38.4%的pwMS患有至少一种并发症;11.3%患有多种并发症.
- 随着年龄的增长,并与更高的残疾相关联 (EDSS ≥4).
- 代谢综合征 (MetS) 在13.7%和胰岛素抵抗 (IR) 在41.6%的评估pWMS中发现.
结论:
- 患有多发性硬化症的患者表现出高患病率的并发性疾病,与残疾和心血管风险增加有关.
- 代谢综合征和胰岛素耐药性经常在患有多发性硬化症的患者中观察到.
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