相关实验视频

Updated: Sep 18, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

在老年人群中使用intradetrusor肉毒素

William Chui^1,2, Alvaro Bazo³, Henry H Yao^1,2,3

¹Department of Urology, Western Health University of Melbourne Melbourne Victoria Australia.

|June 26, 2025

概括

70岁及以上的老年患者的膀过活 (OAB) 在第二个治疗周期中显示出毒素 (BoNT) 注射的疗效降低. 虽然大多数患者经历了症状改善,但年龄是长期结果的关键因素.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
老年病的医生老年病的医生
药理学药理学是指药理学的学科.

背景情况:

耐火性过活性膀 (OAB) 显著影响生活质量.
毒素 (BoNT) 注射是对耐火性OAB的一种既定治疗方法.
患者年龄对BoNT治疗的长期疗效和结果的影响需要进一步研究.

研究的目的:

评估年龄对耐火性过活性膀 (OAB) 患者内毒素 (BoNT) 治疗的长期结果的影响.
在多达四个周期的BoNT治疗后,分析不同年龄层的疗效率和效果持续时间.
鉴定与患者年龄相关的BoNT疗效和不良事件,特别是尿路保留的预测因素.

主要方法:

追溯观察队列研究涉及943名耐火性OAB患者,接受了内突变体BoNT治疗.
患者被分为五个年龄组:≤40,40-49,50-59,60-69和≥70岁.
评估了有效性,效果持续时间和不良事件 (尿路感染,尿路保留),并进行了统计分析以确定显著性 (P < 0.05).

主要成果:

在943名患者中,70岁以上的年龄组的疗效率在四个周期内从84.1%到92.6%不等.
年龄≥70被确定为在第二周期降低BoNT疗效的独立预测因子 (P=0.004).
在周期1和周期2中,男性的尿率高于女性;神经性OAB预测在周期2和周期3中有效性增加.

结论:

在耐火性OAB的老年患者 (≥70岁) 中,年龄是减少肉毒素 (BoNT) 疗效的独立预测因素,特别是在第二次治疗周期.
尽管如此,所有年龄组在BoNT注射后,患者报告的结果指标 (PROM) 均有所改善.
进一步的研究可能会探索特定年龄的治疗策略,以优化老年人的BoNT结果.

关键词:

植物 (botulinum) 是一种植物.这是一个detrusor驱逐器.有效性有效性有效性.老年人的医疗服务失禁失禁失禁是什么意思

更多相关视频

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles

Published on: June 13, 2017

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Published on: November 9, 2016

相关概念视频

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...

Skeletal Muscle Relaxants: Adverse Effects

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...

Urinary Tract Calculi III: Medical Management

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...