内脏脂肪指数和估计的脉冲波速度之间的关系:来自NHANES数据库的见解
Yanwei Liu1, Shiqiang Yang2,3, Jun Wei1
1Department of Neurology, The First People's Hospital of Yibin, Yibin, China.
Frontiers in nutrition
|June 26, 2025
概括
升高的内脏脂肪指数 (VAI) 与增加的动脉硬性 (ePWV) 有关,特别是低于VAI 1.48. 这一发现突显了腹部肥胖症.
科学领域:
- 心血管疾病研究研究
- 肥胖和代谢研究 肥胖和代谢研究
- 血管健康调查 血管健康调查
背景情况:
- 肥胖和动脉硬是已确定的心血管疾病 (CVD) 风险因素.
- 内脏脂肪指数 (VAI) 和估计的脉冲波速度 (ePWV) 之间的特定关系仍然未得到充分研究.
研究的目的:
- 调查内脏脂肪指数 (VAI) 和估计的脉冲波速度 (ePWV) 之间的关联.
- 探索潜在的非线性关系,并确定这个协会的拐点.
主要方法:
- 利用来自国家健康和营养检查调查 (NHANES) 数据库 (2007-2016) 的横截面数据.
- 用有限的立方线分析来评估非线性关系.
- 进行了加权线性回归,子组和灵敏度分析,以进行可靠的关联评估.
主要成果:
- 在VAI和ePWV之间观察到一个"反转L"非线性关系 (非线性P<0.001),其拐点在VAI1.48.
- 证实了VAI和ePWV之间的显著正相关性 (β = 0.1,P < 0.001),在多变量模型和VAI四分位数中一致.
- 在子组和敏感性分析中,这种关联仍然很强.
结论:
- 升高的VAI与增加的ePWV显著相关,特别是VAI水平低于1.48.
- 这种关联独立于多个混因素,强调了腹部肥胖在动脉样硬化中的作用.
- 针对腹部肥胖是减轻心血管风险的关键.
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