1型糖尿病中的代谢干扰与代谢功能障碍相关的脂肪性肝病相关
Adeyinka Taiwo1,2, Ronald A Merrill2,3, Linder Wendt4
1Division of Endocrinology, Department of Internal Medicine, University of Iowa Health Care, Iowa City, IA, United States.
Frontiers in endocrinology
|June 26, 2025
概括
在1型糖尿病 (T1D) 中,代谢功能障碍相关的脂肪性肝病 (MASLD) 与更高的BMI和胰岛素剂量有关. 关键的代谢变化包括高葡萄糖基质,氨基酸,胺和甲.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢学 代谢学 代谢学
- 内分泌学 在内分泌学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是代谢综合征的肝脏表现.
- 虽然在2型糖尿病 (T2D) 中得到了广泛的研究,但在1型糖尿病 (T1D) 中MASLD的发病和严重程度仍然不太清楚.
研究的目的:
- 调查和确定与T1D患者的MASLD相关的特定代谢干扰.
- 与没有MASLD的患者相比,描述T1D患者的代谢概况.
主要方法:
- 一项涉及30名患有T1D的参与者的横截面研究.
- 根据FibroScan结果,参与者被分为MASLD (病例) 和非MASLD (对照) 组.
- 血代谢和脂质组分析是在过夜禁食后进行的.
主要成果:
- 在30名参与者中,有17人患有MASLD. 这些病例的BMI和每日胰岛素剂量较高.
- 马斯尔德组显示高水平的葡萄糖原基质 (pyruvate,乳酸),氨基酸 (阿拉宁,谷氨酸,氨酸) 和人类酸.
- 脂管组显示胺,二甲和三甲的含量增加;在MASLD组中,甲素 (异甲素,L-棕甲素) 的含量也增加.
结论:
- 患有T1D和MASLD的个体表现出胰岛素抵抗的特征.
- 代谢变化表明T1D患者的葡萄糖生成增强,脂质合成受损,TCA循环活性改变.
- 这些发现突出了T1D患者与MASLD不同的代谢概况,需要进一步调查.
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