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Updated: Sep 18, 2025

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport
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转化最小生理学基础的药理动力学模型,用于转移素受体介导的大脑输送抗体

Morris Muliaditan1, Tamara J van Steeg1, Lindsay B Avery2

  • 1Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands.

mAbs
|June 26, 2025
PubMed
概括

开发针对大脑疾病的双特异性抗体 (bsAbs) 是一个挑战. 这项研究创建了一个模型,以优化转移素受体 (TfR) 结合,以增强大脑传递,并从非人类灵长类动物数据中预测人类疗效.

关键词:
双特异性抗体 双特异性抗体在TfR中穿.大脑传递 大脑传递在mPBPK建模中使用mPBPK.基于模型的药物开发 (MIDD)药物动力学 (PK) 是指

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