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孕前的最新情况:发病,生物标志物,诊断和管理

Pei-Lun Lee¹, Paola Gudino¹, Chinweizu Deborah Umana²

¹From the Department of Medicine, Jacobi Medical Center, Bronx, NY.

Cardiology in review

|June 26, 2025

概括

孕前,一种影响全球2~4%的妊娠并发症,涉及血管新生失衡. 早期检测和管理对孕产妇和胎儿健康至关重要,目前正在研究新型治疗方法.

科学领域:

产科和妇科产科和妇科
孕产妇和胎儿医学孕产妇和胎儿医学
心血管研究研究心血管研究

背景情况:

孕前会影响2-4%的怀孕,导致显著的孕产妇和胎儿发病率/死亡率.
早期发病的孕前 (<34周) 涉及异常的胎盘;晚期发病 (>34周) 涉及输液/代谢不匹配.
血管源性失衡 (增加抗血管源性因素,如sFlt-1,可溶性内分泌物;减少血管源性PlGF) 是关键因素.

研究的目的:

综合审查产前的发病,诊断,生物标志物和管理.
突出血管新生失衡在孕前发展中的作用.
讨论当前和新兴的治疗策略以及长期健康影响.

主要方法:

综述现有的关于子宫前的文献.
对诊断标准和生物标志物的分析,包括sFlt-1/PlGF比率.
检查预防策略,当前的治疗方法和新的治疗研究.

主要成果:

孕前的诊断包括高血压,蛋白尿,末端器官损伤或子宫胎盘功能障碍.
sFlt-1/PlGF比率是FDA批准的用于预孕风险评估的工具.
低剂量阿司匹林是高风险妇女的主要预防策略.

结论:

生产是最终的治疗方法,但新型疗法 (阿菲雷斯,siRNA,甲胺等) 仍然存在. 正在接受调查.
患有妊娠前史的女性长期增加了心血管,脏和代谢风险.
怀孕后全面的随访对于管理长期健康风险至关重要.

关键词:

心血管疾病心血管疾病慢性脏疾病慢性脏疾病最终阶段的脏疾病.这种高血压,高血压.孕前症是什么意思怀孕怀孕怀孕怀孕怀孕

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