在血清阳性脏移植接受者中,在预防性策略下,细胞巨乳病毒感染具有多种免疫风险
Mun Chae Choi1,2, Minyu Kang3,4, Hwa-Hee Koh3,4
1Department of Surgery, Armed Forces Capital Hospital, Seongnam, South Korea.
Journal of medical virology
|June 26, 2025
概括
细胞巨乳病毒 (CMV) 感染显著影响移植接受者,增加了移植损失和死亡的风险. 优化预防策略至关重要,特别是在接受预防管理的高风险患者中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 细胞巨乳病毒 (CMV) 感染是移植后最常见的病毒感染.
- 高风险患者经常受到强大的免疫抑制,增加了CMV的担忧.
- 使用预防策略,但CMV发病率和结果需要进一步研究.
研究的目的:
- 确定移植接受者中CMV感染的发病率和结果,具有不同的免疫风险.
- 评估预防性策略在控制CMV方面的有效性.
- 确定与CMV感染相关的风险因素和保护因素.
主要方法:
- 对614名CMV血清阳性移植接受者进行了预防策略的分析.
- 包括免疫不相容的移植 (ABO和HLA) 的患者.
- 随访时间中位数为60个月,使用多变量和考克斯回归分析.
主要成果:
- 在57.7%的患者中发生CMV感染.
- 独立的危险因素包括接受者的年龄较大,已故的捐赠者,rituximab和抗胸细胞球蛋白.
- 拉巴胺素抑制剂的使用对哺乳动物的目标是对CMV感染进行保护.
结论:
- 冠状病毒感染独立地与死亡审查的移植损失和全因死亡率的风险增加有关.
- 这些发现凸显了对高风险脏移植接受者进行优化CMV预防的需要.
- 建议采取加强的预防策略或根据风险调整的预防措施.
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