慢性肺炎和吸入治疗对肺癌患者死亡率的影响
Jinwoo Lee1, Jiyu Sun1, Hyun Woo Lee2
1National Cancer Center, Goyang, Gyeonggi-do, Korea (the Republic of).
Annals of the American Thoracic Society
|June 26, 2025
概括
慢性阻塞性肺病 (COPD) 显著增加了肺癌患者的死亡率. 早期发现COPD并使用双重支气管扩展剂 (LABA/LAMA) 治疗可以改善生存结果.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 临床流行病学 临床流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 对肺癌患者结局的影响以及吸入疗法的疗效仍然不清楚.
- 关于COPD吸入治疗改善肺癌患者临床结果的证据有限.
研究的目的:
- 为了确定COPD是否会加剧肺癌患者的结果.
- 调查吸入性COPD治疗方法在改善这一群体的生存率方面的潜力.
主要方法:
- 使用韩国中央癌症登记 (K-CURE) 数据库 (2012-2019) 的回顾性队列研究.
- 包括40岁以上的肺癌患者和健康查记录.
- 将COPD分为COPD和非COPD组,COPD患者通过吸入治疗使用进一步分类.
- 主要结果:全因死亡率;次要结果:医疗保健资源利用率.
主要成果:
- 在113,071名肺癌患者中,COPD被诊断在33.7%的患者中,并且与较高的全因死亡率 (aHR=1.327) 相关.
- 慢性肺炎患者的类固醇/抗生素使用增加,住院和急诊室访问增加.
- 在COPD患者的吸入治疗与较低的3个月死亡率相关 (aHR=0.934),LABA/LAMA双重治疗显示出显著的生存益处.
结论:
- 慢性肺炎是导致肺癌患者临床结果恶化的重要因素.
- 通过LABA/LAMA双重支气管扩展剂治疗,肺癌COPD患者的死亡率有所改善.
- 早期发现COPD和及时启动吸入疗法,特别是LABA/LAMA,对于改善肺癌患者的生存率至关重要.
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