在45-49岁的个体中坚持多目标便DNA测试,患有结肠直肠癌的平均风险
Mallik Greene1, Mark Camardo1, A Burak Ozbay1
1Exact Sciences Corporation, Madison, Wisconsin, USA.
Clinical and translational gastroenterology
|June 26, 2025
概括
近69%的45-49岁的成年人坚持使用多目标便DNA (mt-sDNA) 测试进行结肠直肠癌 (CRC) 查. 数字通信显著提高了这一重要的CRC查方法的坚持率.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 更新的结肠直肠癌 (CRC) 查指南现在包括45-49岁的个体,这是由于年轻人群中的CRC发病率上升.
- 多目标便DNA (mt-sDNA) 测试为这个年龄组中的平均风险个体提供了一个非侵入性的家庭查选项.
- 在45-49岁的人群中,对mt-sDNA查的真实遵守率以前没有得到量化.
研究的目的:
- 量化结肠直肠癌 (CRC) 查对多目标便DNA (mt-sDNA) 测试的坚持率,在45-49岁的人群中.
- 在这个人口群体中确定影响 mt-sDNA 查的因素.
- 提供现实世界的数据,为改善CRC查普及的策略提供信息.
主要方法:
- 追溯分析了1,126,523名年龄在45-49岁的个体,平均CRC风险和没有先前的mt-sDNA测试.
- 遵守定义为在处方后一年内返回有效的mt-sDNA测试套件.
- 后勤回归用于识别遵守的预测因素,包括通信方法和保险类型.
主要成果:
- 在一年内,mt-sDNACRC查的总体遵守率为68.9%.
- 当测试是由胃肠科医生 (75.5%) 和商业保险 (70.9%) 处方时,依从性更高.
- 接收数字通信 (例如短信) 的个人表现出明显更高的坚持 (54.9%没有与通信).
结论:
- 大多数年龄在45-49岁的人都接受了mt-sDNACRC查,但仍有改进的余地.
- 数字通信策略似乎是提高对mt-sDNA查的坚持的一个关键因素.
- 有针对性的干预措施,特别是利用数字推广,可能会增加45-49岁年龄组的CRC查率.
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