暴露于环境颗粒物对患肺结核风险的影响:系统性审查和元分析
Nisha Kumari1, Shashi Bhushan Singh1, Dewesh Kumar1
1Department of Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Lung India : official organ of Indian Chest Society
|June 26, 2025
概括
暴露于空气污染,特别是细颗粒物 (PM2.5) 和PM10,显著增加患肺结核 (PTB) 的风险. 公共卫生干预对于减轻这些风险至关重要,特别是在城市和工业区.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 构成了严重的全球健康威胁,在受污染的地区产生显著影响.
- 环境颗粒物 (PM) 与结核病风险之间的确切关系需要进一步阐明.
研究的目的:
- 系统地审查和元分析暴露于环境颗粒物 (PM10和PM2.5) 与肺结核 (PTB) 风险之间的关联.
主要方法:
- 在PubMed,Web of Science和Cochrane数据库中进行了全面的文献搜索.
- 在研究选择,数据提取和质量评估方面遵循了PRISMA指南 (2020).
- 在元分析中使用随机效应模型来估计聚合效应大小并评估异质性.
主要成果:
- 长期暴露于PM2.5与PTB风险增加26% (RR=1.26) 相关,而长期暴露于PM10则增加了7% (RR=1.07).
- 短期暴露也显示PM2.5 (10%) 和PM10 (7%) 的PTB风险增加.
- 亚组分析表明,女性的PTB风险增加高于男性的PM类型.
结论:
- 暴露于颗粒物是肺结核的重要危险因素.
- 颗粒度增加10μg/m3与PTB风险增加有关.
- 有针对性的公共卫生战略是必要的,以减少颗粒物暴露,特别是在弱势群体和高风险地区.
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