用西斯普拉丁或卡博普拉丁进行放射治疗,用于治疗头部和部状细胞癌的帕克利塔塞尔
Marin Abousaud1, Saagar Pamulapati2, Saad Rashid3
1Astellas Pharma Global Development Inc, Astellas Pharma, Northbrook, Illinois.
JAMA otolaryngology-- head & neck surgery
|June 26, 2025
概括
卡博普拉丁/帕克利塔塞尔 (C/P) 在接受化疗或放射治疗的头癌患者中显示出与西斯普拉丁相似的生存结果. 这项研究支持C/P作为无法接受西斯普拉丁的患者的替代品,尽管C/P的副作用更多.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学瘤学 医学瘤学
背景情况:
- 头部和部状细胞癌 (SCCHN) 的治疗通常涉及化疗或放射治疗.
- 卡博普拉丁/帕克利塔塞尔 (C/P) 适用于无法接受西斯普拉丁治疗的患者,但对比数据有限.
研究的目的:
- 为了比较SCCHN患者的临床结果,他们接受了C/P与cisplatin同时接受放射治疗.
- 在最终和术后设置中评估疗效和安全性.
主要方法:
- 回顾性,单一中心的比较有效性研究 (2010-2021年).
- 包括308名SCCHN患者,同时接受C/P或西斯普拉丁的化学放射治疗.
- 分析了局部无复发生存率 (LRFS),无进展生存率 (PFS),远程无转移生存率 (DMFS),总生存率 (OS) 和安全性.
主要成果:
- 在C/P和西斯普拉丁组之间,三年LRFS,PFS,DMFS或OS没有显著差异.
- 三年后的OS率为西斯普拉丁的90.8%,C/P的92.9%.
- C/P与3-4级白血病,贫血,皮肤炎的更高率,以及住院/输卵管安置的增加有关.
结论:
- 在接受化疗或放射治疗的SCCHN患者中,C/P和西斯丁显示出可比的生存结果.
- 对于那些不能耐受西斯的患者来说,C/P是一种可行的替代方案.
- 虽然有效,C / P疗法需要仔细监测增加的毒性.
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