测试酒精使用障碍应急管理的调整:一个随机对照试验
Michael G McDonell1, Sara Parent1, Julianne D Jett1
1Department of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University.
Journal of consulting and clinical psychology
|June 26, 2025
概括
应急管理 (CM) 修改并没有改善成年酒精使用障碍 (AUD) 的酒精使用结果. 然而,与基线相比,参与者在CM期间的酒精消费量有所减少,重饮者反应不太好.
科学领域:
- 成 药物 药物 药物 药物
- 行为心理学 行为心理学
- 临床试验 临床试验
背景情况:
- 酒精使用障碍 (AUD) 是一种慢性复发性疾病.
- 应急管理 (CM) 是一种基于证据的行为干预,用于AUD.
- 预测CM无反应对于量身定制治疗至关重要.
研究的目的:
- 为了评估AUD和高基线尿乙基葡萄糖 (uEtG) 水平的成年人修改的CM干预措施.
- 评估干预修改是否改善了对标准CM不响应者的响应率.
- 调查干预前重度饮酒对CM有效性的影响.
主要方法:
- 158名患有AUD和严重精神疾病的成年人被随机分配到通常的,高幅度的或塑造CM.
- 尿液中乙基葡萄化物 (uEtG) 水平用于监测酒精戒断,并定义重度饮酒 (≥500 ng/mL).
- 主要结局是干预期间uEtG阴性样本的比例.
主要成果:
- 在这三个干预组中,在CM有效性方面没有发现显著差异.
- 与诱导期相比,参与者在CM期间的酒精使用量减少了 (提交uEtG阴性样本的可能性增加了4.2倍).
- 干预前重度饮酒 (uEtG ≥500 ng/mL) 的个人在CM期间实现戒断的可能性较低.
结论:
- 经过修改的CM干预措施并没有提高这种高风险AUD人群的酒精使用减少.
- 总的来说,CM导致与基线相比,酒精消费减少.
- 干预前的大量饮酒模式确定了对CM的独特反应轨迹.
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