骨质疏松症与饮酒者心血管疾病死亡率和全因死亡率的增加有关:一个使用NHANESES数据的队列研究
Xiaoqin Qu1,2, Jingcheng Jiang3
1Medical Imaging Center, the Second People's Hospital of Yibin, Yibin, China.
PloS one
|June 26, 2025
概括
骨质疏松症显著增加了酒精消费者的死亡风险. 患有骨质疏松症的人面临更高的死因和心血管疾病死亡的可能性.
科学领域:
- 老年学与公共卫生
- 骨质新陈代谢和疾病
- 心血管健康 心血管健康
背景情况:
- 骨质疏松症以低骨密度和高骨折风险为特征,是全球日益严重的健康问题,特别是在老龄化人口中.
- 虽然已知酒精对骨健康的有害影响,但其对骨质疏松症患者死亡风险的影响尚不清楚.
- 这项研究通过检查骨质疏松症与美国成年人饮酒死亡率之间的联系来弥补这一差距.
研究的目的:
- 调查骨质疏松症和心血管疾病 (CVD) 死亡率之间的关联.
- 检查骨质疏松症与全因死亡率之间的关联.
- 分析这些协会在美国成年人消费酒精.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2005-2018) 的前性队列研究.
- 包括12178名饮酒成年人 (≥20岁);骨密度通过DXA评估,骨质疏松症根据世卫组织T-score标准定义 (≤-2.5).
- 与国家死亡指数 (NDI) 相关的死亡率数据;多变量考克斯回归分析了协会,对共变量进行调整.
主要成果:
- 卡普兰-梅尔分析显示,骨质疏松症患者的全因和心血管疾病死亡率较高 (Log-rank P < 0.001).
- 经过调整的考克斯回归显示,骨质疏松症与1.60倍增加的全因死亡风险 (HR=1.60,P < 0.001) 和1.55-倍增加的心血管疾病死亡风险 (HR=1.55,P=0.025) 相关.
- 在分层分析 (年龄,性别,吸烟,心血管疾病风险因素) 中发现一致的结果,没有显著的相互作用.
结论:
- 骨质疏松症与饮酒的人群中所有原因和心血管疾病死亡风险的增加有显著的关联.
- 这些发现强调了进一步研究潜在机制的必要性.
- 结果强调了为这一弱势群体制定有针对性的预防策略的重要性.
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