可转移元素的表达与人类的性染色体数量有关
Jordan Teoli1,2,3,4, Miriam Merenciano2, Marie Fablet2,5
1Laboratoire de Biochimie et Biologie Moléculaire, Centre de Biologie et Pathologie Est, Hospices Civils de Lyon, Bron, France.
PLoS genetics
|June 26, 2025
概括
Y染色体可能会通过增加可转移元素 (TE) 表达来影响男性的寿命. 这项研究发现Y染色体存在和更高的TE活性之间存在联系,这表明寿命中性别差异的潜在机制.
科学领域:
- 人类生物学 人类生物学
- 遗传学 遗传学 是一个
- 衰老的研究研究.
背景情况:
- 女性通常比男性活得更长,这一现象还没有完全解释.
- 假设Y染色体会对男性的寿命产生负面影响.
- 衰老可能涉及可转移元素 (TE) 的抑制减少,导致有害影响.
研究的目的:
- 研究人类的性别染色体组成和可移植元素 (TE) 表达之间的关联.
- 探索老年男性和女性之间的TE表达是否不同.
主要方法:
- 分析来自不同类型 (46,XX, 46,XY, 47,XXY, 47,XYY) 的个体的血液转录组数据.
- 检查已发表的转录组数据 (GTEx项目) 以比较老年男性与女性的TE表达.
主要成果:
- 观察到Y染色体的存在和数量与全球TE表达之间存在正相关性.
- 这种关联扩展到几个特定的TE子家族.
- 在GTEx数据集中,在老年男性和女性之间没有发现TE表达的显著差异,这可能是由于数据异质.
结论:
- 性染色体含量,特别是Y染色体,与TE表达水平有关.
- 这一发现为Y染色体对男性寿命的潜在毒性基因组影响提供了新的视角.
- 需要进一步的研究来阐明TE表达在基于性别的寿命差异中的作用.
相关概念视频
The Ratio of X Chromosome to Autosomes
8.8K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.8K
X and Y Chromosomes
26.8K
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
26.8K
Dosage Compensation
6.3K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
6.3K
Overview of Transposition and Recombination
16.1K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
16.1K
Non-LTR Retrotransposons
11.9K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.9K
LTR Retrotransposons
17.9K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
17.9K


