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循环瘤DNA作为一种生物标志物,用于对无塑性甲状腺癌的疾病监测

Sarah Hamidi¹, Ramona Dadu¹, Priyanka C Iyer¹

¹Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX.

JCO precision oncology

|June 26, 2025

概括

循环瘤DNA (ctDNA) 显示出高特异性和积极的预测价值,用于监测形甲状腺癌 (ATC) 的进展. 这种血液检测可以在标准监测方法之外帮助治疗决策.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断
基因组学就是基因组学.

背景情况:

无塑性甲状腺癌 (ATC) 是一种具有不良预后的侵袭性恶性瘤.
早期发现ATC进展对于及时调整治疗至关重要.
循环瘤DNA (ctDNA) 为检测分子残留疾病提供了一种微创方法.

研究的目的:

评估ctDNA作为ATC患者疾病监测生物标志物的临床实用性.
评估基线ctDNA与疾病状况的相关性.
为了确定ctDNA在检测系统治疗期间复发或进展的有效性.

主要方法:

45名ATC患者的回顾性队列研究,基线ctDNA.
ctDNA与成像和/或病理学的相关性.
在全身治疗期间对31名随访ctDNA患者进行二次分析,以检测复发/进展.

主要成果:

在93%的患者中,基线ctDNA与疾病状况相关.
随访ctDNA显示高特异性 (100%) 和正预测值 (100%) 检测复发/进展.
对复发/进展的ctDNA检测灵敏度在1组为77%,在2组为78%.

结论:

ctDNA是监测ATC的有价值和有前途的生物标志物.
ctDNA的高特异性和PPV支持其在临床实践中的使用.
将ctDNA纳入监测策略可以增强ATC患者的治疗决策.

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