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在多发性硬化症患者中fingolimod的有效性:一个开放的标签研究

Fereshteh Ashtari¹, Maryam Pirmoradian², Aryan Kavosh³

¹Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Multiple sclerosis and related disorders

|June 26, 2025

概括

在多发性硬化症患者和脊髓病变患者的芬戈利莫德治疗显示,复发减少,但残疾增加. 脊髓干扰可能表明不太有利的结果,这表明需要个性化治疗方法.

科学领域:

神经学神经学
免疫学免疫学免疫学
临床研究临床研究

背景情况:

脊髓损伤在多发性硬化症 (MS) 中很常见,并导致残疾.
关于fingolimod在患有脊髓损伤的MS患者中的疗效的研究是有限的.

研究的目的:

评估fingolimod在患有脊髓损伤的多发性硬化症 (pwMS) 患者的有效性和安全性.
为了比较pwMS中带有和没有脊髓干扰的结果.

主要方法:

一个前性队列研究,对119名pwMS患者进行了一年的fingolimod治疗.
收集的数据包括人口统计,MRI活动,每年复发率 (ARR) 和扩展残疾状况尺度 (EDSS).

主要成果:

芬戈利莫德在两组中都降低了ARR和大脑病变.
没有脊髓病变的PwMS显示EDSS有所改善,而有病变的PwMS显示EDSS有所增加.
脊髓干扰与更高的治疗后EDSS和ARR有关.

结论:

用fingolimod治疗的脊髓损伤的PwMS具有较不有利的残疾结果.
增加EDSS可能是由于不依赖复发活动 (PIRA) 的进展.
考虑到脊髓损伤的存在对于pwMS的治疗选择至关重要.

关键词:

改变疾病的治疗方法.在Fingolimod中使用.多发性硬化症是多发性硬化症.复发复发的情况脊髓是指脊髓中的一些部分.

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