肝细胞生长因子:心脏粉症中的心脏功能,死亡率和疾病亚型的标记物
Margrethe Flesvig Holt1, Annika E Michelsen2, August Flø3
1Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
JACC. Advances
|June 26, 2025
概括
血中的肝细胞生长因子 (HGF) 在诊断心脏粉样性病 (CA) 和预测患者结果方面表现有前途. 升高的HGF水平与心力衰竭的严重程度和CA患者的预后较差相关.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 蛋白质组学是指蛋白质组学.
背景情况:
- 心脏 Amyloidosis (CA) 诊断往往会延迟,影响患者的预后.
- 血生物标志物为加快诊断和提高预后准确性提供了一个潜在的解决方案.
研究的目的:
- 为了识别循环中的蛋白质生物标志物,区分CA与心力衰竭 (HF) 没有氨基粉症.
- 评估已识别的生物标志物与患者结局的相关性,包括全因死亡率.
主要方法:
- 针对性蛋白质性查对 transthyretin CA,HF 和健康对照 (HC) 的患者进行.
- 免疫检测验证了更大的队列中的蛋白质水平,包括跨甲状腺素CA,轻链CA,HF和HC.
- 多变量通用线性模型和接收器运行特征分析用于比较和结果关联.
主要成果:
- 蛋白质组查发现了99种候选蛋白质;其中4种在CA和HC中升高.
- 肝细胞生长因子 (HGF) 和C-X-C动机化学联体9的CA比HF高.
- HGF水平与心脏功能相关,并且表现出强大的区分能力来预测所有原因死亡率 (AUC = 0.80).
结论:
- 血HGF作为潜在的查生物标志物用于心脏粉样性病.
- 升高的HGF水平表明CA患者的心力衰竭更严重,预后更差.
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