人的食道中的残留菌株和形态学:取决于位置,年龄和性别
Dimitrios P Sokolis1, Stavroula A Papadodima2, Christos Manopoulos3
1Laboratory of Biomechanics, Center of Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Journal of biomechanics
|June 26, 2025
概括
人的食道生物力学是很少理解的. 这项研究分析了人类食道组织的残余变形和开口角度,发现了随长度增加的层特异变化,为模拟提供了关键数据.
科学领域:
- 生物医学工程 生物医学工程
- 胃肠病学 胃肠病学
- 人类解剖学 人类解剖学
背景情况:
- 与动物模型相比,人类食道的生物力学数据有限.
- 了解食道组织机制对于模拟食物运输和开发临床干预至关重要.
研究的目的:
- 分析人类食道组织的残留变形和零压力配置.
- 为了研究食道生物力学中的与年龄和性别相关的变化.
主要方法:
- 从21具尸体 (21-84岁) 的食道组织中分析了剩余的变形和开口角.
- 放射切割和分离层 (粘膜-膜和肌肉) 的食道环.
- 在剖析前和之后对拍摄的组织部位进行图像分析.
主要成果:
- 粘膜-膜下膜开口角沿食道增加,特别是在年轻的受试者和两性.
- 由于粘膜-膜扩张,完整的壁厚随着年龄的增长而增加,特别是在食道上部.
- 雄性表现出更宽,更厚的食道,但性别没有显著影响开口角度或残留菌株.
结论:
- 这项研究提供了人类食道残留菌株和生物机械性质的全面数据库.
- 这些发现增强了食道运输的计算模拟,并为临床干预提供了信息.
- 开口角和拉伸的特定层变化是理解食道力学的关键.
相关概念视频
Esophageal Strictures-I: Introduction
278
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
278
Esophageal Strictures-II: Clinical Features and Management
163
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
163
Esophagus
1.4K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
1.4K
Barrett Esophagus-I: Introduction
220
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
220
Measurements of Strain
2.2K
Strain quantifies the deformation of a material under force, typically measured as normal strain, which represents the change in length when compared with the original length. Electrical strain gauges are used for enhanced accuracy. These devices consist of a conductive wire mounted on a paper backing that adheres to the material's surface. These gauges operate on the piezoresistive effect, where the wire's electrical resistance changes in response to mechanical deformation. The strain...
2.2K
Barrett Esophagus-II: Clinical Manifestations and Management
318
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
318


