补充剂驱动的铁过载通过炎症生物标志物加速表型衰老:通过抗炎或抗氧化饮食的潜在对抗作用
Bin Li1, Zhu Ming2, Yina Wang2
1Department of Clinical Nutrition, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, PR China; Department of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, 150081, PR China.
Redox biology
|June 26, 2025
概括
过度补充铁可能会加快衰老,特别是那些铁过载的人. 然而,抗炎或抗氧化饮食可以减轻这种风险,而炎症起着关键作用.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 铁对健康有双重影响,其与衰老的关系不明.
- 现型年龄 (PhenoAge) 是生物衰老的生物标志物.
- 炎症和氧化应激与衰老过程有关.
研究的目的:
- 为了研究铁摄入量与PhenoAge加速 (PhenoAgeAccel) 之间的关系.
- 探索炎症和氧化应激在这种协会中的中介作用.
- 识别与补充铁和超载相关的潜在风险.
主要方法:
- 使用NHANES 2017-2018数据进行的横截面研究 (n=8692).
- 权重限制立方线 (RCS) 和通用线性模型 (GLMs) 用于非线性和多变量分析.
- K-意味着对铁的共同暴露模式进行聚类,并进行相互作用和调解分析.
主要成果:
- 在总铁摄入量和PhenoAgeAccel之间观察到U形关系.
- 铁摄入量高于18.441毫克/天与加速衰老有关.
- 补充铁的摄入量,但不是食铁,显示与PhenoAgeAccel的积极关联.
- 补充剂驱动的铁过载 (SDIO) 与食铁参考 (DIR) 相比显示出明显更快的表型衰老.
- 炎症标志物部分介导了与SDIO相关的衰老加速.
- 抗炎或抗氧化饮食抵消了铁过载对衰老的有害影响.
结论:
- 过度补充铁导致铁过载可能通过与炎症相关的途径加速衰老.
- 饮食中铁的摄入量在推水平内似乎不会损害衰老.
- 采用抗炎或抗氧化饮食可以减轻与铁过载相关的衰老风险.
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