主观的药物效应评级预测大麻每天使用大麻的人自我管理大麻
Thomas P Shellenberg1, Justin C Strickland2, Sean D Regnier3
1Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, Kentucky; Department of Psychology, University of Kentucky College of Arts and Sciences, Lexington, Kentucky.
概括
愿意再次服用最好预测日常使用者的大麻自我管理,超过药物喜欢. 这一发现可以改善对新大麻产品滥用潜力的评估.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 神经科学是一个神经科学.
- 监管科学 监管科学
背景情况:
- 对治疗大麻日益增长的兴趣需要准确的滥用潜在预测器来做出监管决策.
- 目前的FDA建议优先考虑药物喜欢等级,但这些可能与实际的药物服用行为不一致.
- 以前的研究表明,主观药物效应和观察到的行为之间存在潜在的分离.
研究的目的:
- 为了确定特定的主观效应是否能在日常大麻使用者中独特地预测大麻自我管理.
- 为了比较各种主观效果评级与实际吸毒行为的预测能力.
主要方法:
- 这是一项回顾性分析,结合了四项先前研究的数据,其中包括89名日常大麻使用者.
- 大麻自我管理程序包括在大麻吸烟和金钱激励之间做出选择.
- 主观影响评级 (例如,好效果,高,镇静/疲劳,喜欢药物,刺激,愿意再次服用) 被分析为预测因素.
主要成果:
- 较高的"愿意再次服用"评分与自行服用活性9四大麻 (THC) 大麻的几率增加有显著的关联.
- 刺激的更高评分与自给药安慰剂大麻的几率下降有关.
- 与药物喜欢相比,愿意再次服用表明大麻自我管理的预测价值更强.
结论:
- 重复使用意愿的主观评分应该被认为是对大麻素产品的人类滥用潜力研究的主要结果指标.
- 优先考虑与吸毒行为更好地相关的主观措施,可以加强对新型大麻产品的监管评估.
- 这项研究通过确定更具预测性的主观结果来完善对大麻制品滥用责任的评估.
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