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唐申配方通过调节 podocyte 中的 BAX 交叉调节来缓解多克索鲁比辛诱导的毒性

Yuxi Li¹, Ge Hong², Liang Peng³

¹State Key Laboratory of Respiratory Health and Multimorbidity, Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, PR China; Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, PR China; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|June 26, 2025

概括

唐申配方 (TSF) 通过抑制 podocyte 亡和 pyroptosis 来保护脏免受多克索鲁比 (DOX) 损伤. 作为TSF的一个组成部分的金赛诺化物显示出最有效的抑制BAX,BAX是细胞死亡途径中的关键蛋白质.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

多克索鲁比 (DOX) 化疗会导致严重的损伤 (毒性).
唐山配方 (TSF) 是一种传统的中医药,在糖尿病脏病和动物模型中显示出脏保护作用.

研究的目的:

调查TSF减轻DOX诱导的毒性的分子标和机制.
在TSF中识别潜在的治疗化合物,用于治疗化疗引起的损伤.

主要方法:

利用了蛋白质因子微阵列,生物信息学,细胞系 (MPC5) 研究和分子对接.
进行了体外和体内实验,以阐明TSF和DOX毒性之间的病理关系.
确定了潜在的小分子抑制剂,针对关键路径.

主要成果:

治疗TSF显著降低了白蛋白尿和改善了脏组织病理.
TSF调节了与亡和烧亡相关的信号通路,在DOX处理的老鼠细胞中抑制了这些过程.
它增加了受体细胞标记物 (WT1,nephrin) 和降低了 pyroptosis标记物 (GSDMD);它还调节了BAX/BCL2平衡.
作为TSF化合物的金赛诺化物显示出BAX和MPC5热的最强抑制作用.

结论:

通过调节 BAX 介导的亡和亡在 podocytes 的交叉,TSF 提供了一种针对急性毒性的新疗法策略.
TSF代表了急性毒性 (AN) 的有前途的草药疗法.
人参化物被认为是抑制BAX水平的最有效成分.

关键词:

巴克斯巴克斯 (BAX) 是一个多克索鲁比诱导的毒性引起的毒性.人参化enoside的使用.细胞是一种细胞.唐山的配方唐山的配方

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