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在孕期婴儿中产前皮质类固醇暴露和新生儿结局
Hao-Wei Chung1, Chia-Hung Yu2, Chiao-Yun Huang3
1Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shiquan 1st Rd., Sanmin Dist., Kaohsiung City 807378, Taiwan; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shiquan 1st Rd., Sanmin Dist., Kaohsiung City 807378, Taiwan; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, No. 75 Po-Ai Street, Hsinchu 300, Taiwan; Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, No. 482, Shanming Rd., Siaogang Dist., Kaohsiung City 812, Taiwan; Center for Big Data Research, Kaohsiung Medical University, No. 100, Shiquan 1st Rd., Sanmin Dist., Kaohsiung City 807378, Taiwan.
用于威胁过早分娩的产前皮质类固醇 (ACS) 增加了预产期婴儿的短期风险,包括更小的妊娠年龄和黄. 这些风险在妊娠28周至33周之间暴露于ACS时更高.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿医学 新生儿医学
- 围产期流行病学 围产期流行病学
背景情况:
- 产前皮质类固醇 (ACS) 是用于早产的标准,以减少呼吸困难.
- 有限的数据存在于短期新生儿在到期分娩中ACS的风险.
- 妊娠年龄对ACS在满期怀孕中的暴露的影响尚不清楚.
研究的目的:
- 检查 ACS 暴露与适时出生的婴儿新生儿结局之间的关联.
- 评估ACS暴露时的妊娠年龄如何影响这些结果.
主要方法:
- 使用台湾的健康数据库进行了回顾性,基于人口的队列研究.
- 与未暴露的婴儿相比,孕期婴儿暴露于ACS,以威胁过早分娩.
- 多变量逻辑回归分析了新生儿结果.
主要成果:
- ACS暴露发生在0.6%的终产婴儿中.
- 暴露的婴儿显示SGA,NICU入院,败血症,低血糖和黄的比率更高.
- 经过调整后的分析表明,SGA,NICU入院和高 bilirubinemia 的几率更高.
- 在28-33周之间的暴露增加了氧气治疗和TTNB的几率.
结论:
- 暴露于ACS与早产婴儿的短期新生儿并发症增加有关.
- 特别是在妊娠28周到33周之间暴露时,风险特别高.
- 即使在导致到期分娩的怀孕中,ACS也可能增加新生儿发病率.
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