椎间盘退化增加了转移性脊椎的表面应变,在压缩和曲方面是如此,但在扭曲方面却不是如此
Margherita Pasini1, Giulia Cavazzoni1, Enrico Dall'Ara2
1Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Via Umberto Terracini 28, 40131, Bologna, Italy.
概括
椎间盘 (IVD) 退化显著增加了邻近转移性脊椎的压力应变,特别是在轴向压缩和曲过程中. 健康的脊椎表现出较少的应变变异,突出显示了转移性骨头对脊柱生物力学变化的易感性.
科学领域:
- 生物医学工程 生物医学工程
- 整形外科 整形外科 整形外科
- 脊柱生物力学 脊柱生物力学
背景情况:
- 椎间盘 (IVD) 对脊柱生物力学至关重要.
- IVD条件对转移性脊椎机制的影响还未得到充分研究.
- 在IVD中与年龄相关的变化改变了脊柱的生物力学行为.
研究的目的:
- 调查椎间盘退化如何影响相邻健康和转移性脊椎的应变.
- 在不同的负荷条件下,由于IVD退化,量化脊椎应变的变化.
主要方法:
- 准备了8个人类脊柱段 (每一个4个脊椎),其中包括健康的脊椎和转移的脊椎.
- 使用酶性原酶溶液诱导的椎间盘间退化.
- 在IVD退化之前和之后进行生物力学测试 (轴向压缩,曲,扭曲).
- 使用3D-数字图像相关性 (DIC) 测量了表面脊椎菌株.
主要成果:
- 椎间盘退化显著增加了转移性脊椎中介压缩应变 (轴压缩+25.6%,曲+43.7%).
- 增加的菌株被定位在退化的磁盘附近.
- 与转移性脊椎相比,健康的脊椎表现出较少显著的菌株变异.
- 扭转负荷在转移的脊椎和对照脊椎中显示了微不足道的应变差异.
结论:
- 椎间盘退化改变了邻近脊椎的应变分布.
- 转移性脊椎更容易受到IVD退行变化的增加菌株的影响.
- 健康的脊椎在不同方向上表现出强大的承载能力.
- 由于IVD退化,脊柱边界条件的轻微变化可能会严重影响转移性骨稳定性.
相关概念视频
Normal Strain under Axial Loading
670
Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
670
Structural Joints: Cartilaginous Joints
2.7K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
2.7K
Vertebral Column: Regions and Curvature
4.1K
The vertebral column or spine is a flexible column that supports the head, neck, and body and allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
4.1K
General Structure of a Vertebra
3.6K
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...
3.6K
Bending of Curved Members - Strain Analysis
230
The mechanics of deformation in curved members, such as beams or arches, under bending moments, involve complex responses. When such a member, symmetric about the y-axis and shaped like a segment of a circle centered at point C, is subjected to equal and opposite forces, its curvature and surface lengths change significantly. This alteration results in the shift of the curvature's center from C to C', indicating a tighter curve.
The important part of bending analysis for such a member...
The important part of bending analysis for such a member...
230
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
332
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
332


