便挥发性有机化合物用于结直肠癌检测:系统性审查和元分析
Neha Bhattacharyya1, Ziya Sastimoglu1, David Armstrong2
1Electrical and Computer Engineering, McMaster University, Hamilton, Ontario, Canada.
Computers in biology and medicine
|June 26, 2025
概括
便挥发性有机化合物 (VOC) 分析显示,对结直肠癌 (CRC) 检测具有很高的准确性. 标准化和验证对于其作为非侵入性诊断工具的临床使用至关重要.
科学领域:
- 生物医学诊断 生物医学诊断
- 癌症研究 癌症研究
- 分析化学是一种分析化学.
背景情况:
- 便挥发性有机化合物 (VOC) 分析是一种有前途的非侵入性方法,用于检测结直肠癌 (CRC).
- 临床采用受限于方法的变化,缺乏标准化和不足的验证.
- 本系统性审查和元分析通过评估诊断性能和未来潜力来解决这些局限性.
研究的目的:
- 系统地审查和元分析便VOC分析用于CRC检测的诊断性能.
- 探索便VOC分析在CRC监测中的潜在应用和挑战.
- 确定未来研究的关键领域,以促进临床翻译.
主要方法:
- 对在CRC检测和监测中便VOC分析的研究进行了全面的文献搜索.
- 提取和分析了敏感度,特异性,分析平台和协议的数据.
- 综合诊断准确度指标是从包括的七项研究中计算出来的.
主要成果:
- 便VOC分析显示,用于CRC检测的聚合灵敏度为0.86和特异性为0.90 (SROC AUC为0.89).
- 在一些研究中,机器学习算法实现了高诊断精度,AUC从0.84到0.96.
- 观察到特异性的异质性,方法不一致性和有限的验证数据,影响了概括性和早期检测见解.
结论:
- 程序的标准化和多中心验证研究对于便VOC分析成为可靠的临床工具至关重要.
- 需要进一步进行严格的调查,以克服目前的局限性并加强证据基础.
- 将VOC分析与其他诊断技术相结合,可以提高CRC检测,分期和治疗后监测.
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