人类吸气肌的神经控制. 我们从单一电机单元的研究中学到什么?
Jane E Butler1, Simon C Gandevia1, Anna L Hudson2
1Neuroscience Research Australia, Randwick 2031, Australia; University of New South Wales, Sydney 2052 Australia.
概括
几十年的研究揭示了人类呼吸神经驱动器的复杂组织. 运动单元记录显示肌肉激活不均,以及神经机械匹配的原理,这对于呼吸控制至关重要.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统生理学 呼吸系统生理学
- 发动机控制器的控制器
背景情况:
- 人的呼吸神经驱动是复杂的.
- 单个运动单元的录音提供了关于灵感肌肉控制的见解.
研究的目的:
- 审查30年来对人类呼吸神经驱动器的知识收益.
- 为了说明整个启发性运动神经元池输出的不均性.
- 描述呼吸神经驱动的分级时间和大小.
主要方法:
- 从人类的吸入肌肉中对单个运动单元记录的审查.
- 在安静和自愿的呼吸过程中,对运动神经元池输出的分析.
- 在各种条件下检查隔膜运动单元放电和形态.
主要成果:
- 在隔膜,骨,肋间肌肉和光肌肌肉中产生不均的输出.
- 在运动神经元招募中确定神经机械匹配的原则.
- 在衰老,COPD和脊髓损伤中观察到隔膜运动单元放电的变化.
结论:
- 呼吸神经驱动器是精心组织的,以匹配肌肉的复杂性.
- 神经机械匹配的原则是一般的运动控制原则.
- 增加呼吸动力并不总是与皮质控制变化有关.
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